Malaga 2 Barcelona 4: Pique dedicates goal to newborn son Milan

Holders Barcelona set up a Copa del Rey semi-final with arch-rivals Real Madrid after a thrilling 4-2 second leg win in Malaga.

The La Liga leaders progressed 6-4 on aggregate after drawing 2-2 in the Nou Camp last week, with goals from Pedro, Gerard Pique and late strikes from Andres Iniesta and Lionel Messi putting them through.

Malaga's Joaquin had quickly cancelled out Pedro's opener before Pique struck with a well-taken goal in the second half.

For Milan: Gerard Pique pays tribute to his newborn son after scoring Barcelona's second of the night

Composure: The centre back held his nerve in front of goal

The centre back stayed up the pitch after a set piece, latched onto an inch-perfect Iniesta ball, and rifled the ball home.

After he scored he put his thumb in his mouth, as a touching tribute to his newborn son, Milan.

But former Manchester City and Blackburn striker Roque Santa Cruz clawed another goal back to put the hosts back in the tie after 68 minutes.

However Manuel Pellegrini's side ran out of steam as the game wore on after an impressive first half and Iniesta combined with Cesc Fabregas for a wonderful third after 76 minutes.

World Player of the Year Messi ended the game as a contest with ten minutes to go.

Running the show: Andres Iniesta pulled the strings in midfield

Over you go: Martin Demichelis sends Cesc Fabregas tumbling after a slide tackle

Jose Mourinho's Real beat Valencia 3-1 on aggregate, despite having two players sent off in Wednesday's 1-1 second-leg draw at the Mestalla.

The semi-final first legs are scheduled for next week. On the other side of the draw, Atletico Madrid set up a last four encounter with Sevilla after drawing 1-1 at their city rivals Real Betis to progress 3-1 on aggregate.

Diego Costa scored a valuable away goal, to add to last week's 2-0 victory at the Calderon, after a dreadful misunderstanding in the Betis defence just before half-time.

Chasing a long punt over the top Betis defender Antonio Amaya did not see his keeper Casto Espinosa had raced out of the area and he headed the ball past him allowing Costa to run through and tap into an empty net.

Remember me? Former Manchester City hitman Roque Santa Cruz made it 2-2 after Pique's goal

Man in the middle: Lionel Messi (centre) cut a frustrated figure at times

Perseverance: Messi got his goal in the end to kill the tie off once and for all

La Liga's second-placed side Atletico successfully stifled their hosts until they gave away a penalty in the final minute to concede their first goal in six games in this season's cup competition.

Atletico defender Diego Godin bundled over Jorge Molina in the area and the striker netted from the spot.Sevilla, who beat Atletico 2-0 in the 2010 Cup final, swept aside Real Zaragoza 4-0 on aggregate in their quarter final.